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We thank this reviewer for his or her opinions and recognition that DNL343 has a promising possible as therapy for neurodegenerative illnesses. While our experiments share some similarities to Wong et al., eLifeAlthough additional antifibrotic profit was not observed at 12 months 2, exploratory analyses pointed to the sturdiness of the benefit whic
These findings increase some questions about the regulation of caspase activation. Why are two cleavage situations required to remove the prodomain? Our facts show which the cleavage at D9 is required for cleavage at D28. 1 doable clarification is always that recognition and binding on the D9 site orients the prodomain for cleavage at D28. This wou